High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1고용량 약물 스크리닝을 통해 SARS-CoV-2 Delta 및 Omicron/BA.1의 다양한 경로를 구체적으로 표적으로 하는 진입 억제제 식별 가능Article Published on 2022-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus Alpha antagonist antagonists applied BA.1 Beta Caco2 cells Cathepsin-L cell entry cells cellular entry chlorpromazine Combination Compound D614G Delta drug Drug repurposing Drug screening Entry inhibitor FDA-approved drugs G protein G protein coupled receptor antagonist G-protein help highest identify Infection route inhibit inhibitors lentiviral Lentiviral vector lentiviral vectors mechanism membrane fusion omicron pathway phenothiazine preference pseudotyped pseudovirus pseudovirus pseudoviruses receptor receptor antagonist Receptor binding receptors respiratory responsible resulting SARS-CoV-2 several variant several variants Severe acute respiratory syndrome specific inhibitors spike variant synergistic targets TMPRSS2 variant Variant of concern. viral entry VoC VOCs [DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article
Structural and Biochemical Analysis of the Dual Inhibition of MG-132 against SARS-CoV-2 Main Protease (Mpro/3CLpro) and Human Cathepsin-LSARS-CoV-2 주요 프로테아제(Mpro/3CLpro) 및 인간 카텝신-L에 대한 MG-132의 이중 억제 구조 및 생화학적 분석Article Published on 2021-10-292022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 치료제, [키워드] active site Antiviral strategies binding biochemical catalytic cathepsin Cathepsin-L conditions covalent binding covalent bond COVID-19 pandemic Cys145 cysteine docking drug design dual target inhibitor effective drugs Evidence feature group highlighting Human in silico inhibit inhibited inhibition MG-132 MPro Mpro/3CLPro multi peptidomimetics Perspective protease reducing Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease similarity Structure therapy X-ray diffraction [DOI] 10.3390/ijms222111779 PMC 바로가기 [Article Type] Article